Acetylcholinesterase Blockers
- Acetylcholine [Acetylene torch with coal] activates nicotinic [cigarettes] receptors in neuromuscular junction
- Shortly after release into the synaptic cleft, acetylcholine [Acetylene torch with coal] is normally degraded by acetylcholinesterase [Pac man]
- Reversible blockers tend to end with "-stigmine" [Stick mine]
- Physostigmine [Pfizer stick mine]
- Causes miosis and can be used to treat glaucoma [glued eye]
- Causes bradycardia since acetylcholine is a parasympathetic mediator [snail heart]
- Can enter CNS [Brain], causing convulsions [shaking spinal cord]
- Reverses the actions of atropine [atrophying pine], tricyclic antidepressants, and phenothiazines [Fan sulfur zine]
- Duration of action is approximately 3 hours [3 hour glasses]
- Neostigmine [Neon stick mine]
- Does not enter CNS [Crossed-out brain in "Neo"]
- Antidote for tubocurarine [Curare arrow]
- Treatment of myasthenia gravis [Esthetic grave]
- Duration of action is approximately 3 hours [3 hour glasses]
- Pyridostigmine [Pyramid stick mine]
- Ancient, long duration (6 hours) [Pyramids, clock]
- Physostigmine [Pfizer stick mine]
- Edrophonium [E=mc
2 dropping phone]- Quickly dropping, with short duration of 20 minutes
- Diagnostic agent for myasthenia gravis, where rapid transient improvement is seen upon administration
- Tacrine [Tack rhino] [Tack with rhino on the end]
- Used to treat Alzheimer's disease
- Isoflurophate [is four flouro hate] [F-swastika]
- Organophosphate - damages the acetylcholinesterase enzyme [Pac man] and is therefore irreversible.
- Causes miosis and can be used to treat wide-angle glaucoma [glued eye]
- Echothiophate is a newer variant [Not drawn]
- Pralidoxime [Pee rail ox chime] can displace organophosphates from acetylcholinesterase, but only if administered before organophosphates damage (alkylate) the enzyme
Log in or Sign Up to see the image without "SAMPLE"
View Demo plates
Visual Mnemonic - Acetylcholinesterase Blockers, Tricyclic Antidepressants: Physostigmine, Neostigmine, Pyridostigmine, Edrophonium, Tacrine, Isoflurophate, Echothiophate, Pralidoxime
Copyright 2004-2005 Mediglyphics, all rights reserved.