Anti Parkinson [Bench in a park]
- Parkinson syndrome results from depletion of dopamine-producing neurons in the brain, mostly in older people [Broken dope mine bathing old man in smoke]
- Parkinson-like symptoms can be induced by drugs:
- Haloperidol [Halo peri denture]
- Phenothiazine [Pentagram flaming-sulfur zine]
- Levodopa [Levi jeans dope]
- Choice drug for Parkinson
- Crosses brain-blood barrier (unlike dopamine!) [One leg stepping into the brain]
- Used by remaining dopaminergic neurons as a precursor to dopamine in the brain [Neuron & Levi make dope mine]
- Long duration of action [Hour glass tied to legs]
- Protein-rich foods decrease GI absorption [Chicken drum stick hitting & crumpling the knee]
- Side effects are due to conversion of levodopa to dopamine outside the brain, having systemic effects that include:
- Vomiting [Orange vomit]
- arrhythmias [shaking heart]
- Brown urine [Brown urine with dope mine]
- Carbidopa [Carbon dope] co-administered with levodopa inhibits systemic conversion of levodopa to dopamine, therefore reducing side effects [Carbon dope sitting on the shoulder & cracking dope mines that are trying to enter the body]
- Bromocriptine [bra hiding (brown iodine nipples)]
- Impersonates dopamine by acting on dopaminergic receptors
- Can cause hallucinations [Daydreaming of breasts] and orthostatic hypotension [low BP indicator]
- arrhythmias in people with previous myocardial infarct [Shaking heart]
- Also used to treat gynecomastia and prolactin-secreting tumors (since dopamine normally inhibits prolactin secretion) [Bromocriptine = Hide the brown [nipples]]
- Amantadine [Amen done] [praying man]
- Anti-viral drug with anti-Parkinsonian actions
- Promotes recycling of dopamine [Holding recycling halo] by stimulating re-uptake and synthesis
- Causes hallucinations [psychedelic hypnotic sign], Edema [swollen leg], hypotension, and urinary retention [Full bladder]
- Deprenyl [Deep renal] has another name, Selegiline [Sir elegant that is also a deep renal]
- MAO inhibitor [China's ruler, General Mao Zedong is defeated]
- Antimuscarinic [Incapacitated Musk Ox] agents are also used in the treatment of Parkinson's:
- Benztropine [Benz trophy pine]
- trihexyphenidyl [Tri hex-star fan dill]
- Biperiden [Bee peri dine]
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Visual Mnemonic - Anti Parkinson, Antimuscarinic: Dopamine, Haloperidol, Phenothiazine, Levodopa, Carbidopa, Bromocriptine, Amantadine, Deprenyl, Selegiline, Benztropine, Trihexyphenidyl, Biperiden
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