Methotrexate [met T-rex and he ate the foliage off the tree]

• Interferes with tetrahydrofolate synthesis [depleting foliage with 4 drops of saliva]
  • Leucovorin [white leaf covering] protects folate metabolism from methotrexate
• Treatment for:
  • Breast cancer
  • ALL
  • Burkitt's lymphoma [barking dog bitten in half]
  • Fetotoxic - abortifacient [broken fetus]
  • Choriocarcinoma [malignant tumor of the chorion]
  • Rheumatoid arthritis [drop of saliva soothing painful joint]
• Eliminated in urine, resulting in crystalluria [urinating into the tub with crystals]
• Lung & liver toxicity [cracked lung and liver]
• Rash [red rash spots]
• CNS inflammation [brain on fire]

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Visual Mnemonic - Methotrexate, Leucovorin
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