Muscarinic Blockers, Muscarinic Blocker: Ipratropium, Scopolamine, Atropine mnemonic

Muscarinic Blockers [musk ox is blocked and tied to ground]

Ipratropium ["I don't pee when I see a rat on a rope, yum!"]
- Treatment of asthma and COPD [ass-ma cop scared of the rat]
Scopolamine [scoop of old amine (dung)]
- Heavy doses were used for interrogations [loose tongue scooping up old amine]
- Treatment of motion sickness [ship]
Atropine [atrophying pine] - the prototype muscarinic blocker
- Mydriasis [dilated pupils]
- cutaneous blushing [blush]
- Drying effect (less tears, urinary retention, less sweating) [roots are absorbing and drying off the urine, saliva, etc. Pine is also plugging the bladder]
- Used in treatment of organophosphate insecticide poisoning [roots take up & dry the insecticide]
- Both atropine and scopolamine decrease GI motility [both pine & scoop of old amine blocking the emptying of stomach]
- Low doses induce bradycardia [snail heart tied to pine trunk], but the heart accelerates with higher doses [the heart ran off & broke the leash]
- Increases body temperature [atrophying pine is on fire]
- Penetrates the brain-blood barrier [tip impales the brain]
- 4-hour duration [4 clocks on branches]
- Contraindicated in glaucoma [roots impale and destroy the glued-eye]
- Eliminated via kidneys